Jefferson arranged for Lewis to study under Wistar in Philadelphia during the spring of 1803. Wistar instructed Lewis in anatomy, natural history, and the identification of fossil remains — subjects directly relevant to cataloging the unknown species the expedition would encounter.

Wistar’s particular interest was in paleontology and comparative anatomy. He coached Lewis on what to look for in the way of “megafauna” bones — Jefferson famously hoped the expedition might find living mastodons in the West.

The flowering plant genus Wisteria is named in Wistar’s honor (with an altered spelling by the botanist Thomas Nuttall). His contributions to Lewis’s scientific preparation helped ensure that the expedition’s natural history observations met the standards of the international scientific community.

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