This article provides a forensic examination of Meriwether Lewis’s financial situation from the completion of the expedition through his death in 1809. Danisi documents how Lewis, despite receiving land grants and a salary as Governor of Louisiana Territory, accumulated significant debts related to expedition expenses, land speculation, and the costs of preparing the expedition journals for publication. The article reveals that the federal government’s refusal to honor certain expenditures Lewis had made on behalf of the territory created a financial crisis that compounded his personal difficulties. Danisi argues that understanding Lewis’s financial pressures is essential for interpreting his final months and the circumstances surrounding his death on the Natchez Trace in October 1809.